Cited 0 times in Scipus Cited Count

Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.

DC Field Value Language
dc.contributor.authorMitsuda, N-
dc.contributor.authorOhkubo, N-
dc.contributor.authorTamatani, M-
dc.contributor.authorLee, YD-
dc.contributor.authorTaniguchi, M-
dc.contributor.authorNamikawa, K-
dc.contributor.authorKiyama, H-
dc.contributor.authorYamaguchi, A-
dc.contributor.authorSato, N-
dc.contributor.authorSakata, K-
dc.contributor.authorOgihara, T-
dc.contributor.authorVitek, MP-
dc.contributor.authorTohyama, M-
dc.date.accessioned2011-08-02T02:04:57Z-
dc.date.available2011-08-02T02:04:57Z-
dc.date.issued2001-
dc.identifier.issn0021-9258-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3689-
dc.description.abstractUpon binding to the cAMP-response element of a gene's promoter, the transcription factor known as cAMP-response element-binding protein (CREB) facilitates transcription of many different neuronal genes including those involved with synaptic function. Based on our previous reports of gene structure (GenBank accession number AF029701 ), we now demonstrate that activated CREB binds to the proximal promoter of the human presenilin-1 (PS-1) gene to activate PS-1 transcription in rat and in human neuronal cells. Specific stimulation of the N-methyl-d-aspartate subtype of neuronal glutamate receptors activates CREB and results in increased PS-1 expression. Similarly, treatment with brain-derived neurotrophic factor activates CREB and increases PS-1 expression in a dose-dependent fashion. By using adenovirus vectors expressing dominant negative forms of CREB, we were able to show that induction of PS-1 expression requires the activation of CREB. Conversely, constitutive expression of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) results in activation of CREB and increased PS-1 expression that can be blocked by the addition of selective MEK inhibitors. Our findings suggest a hypothesis where stimulation of N-methyl-d-aspartate receptors signals CREB activation to enhance PS-1 gene product expression that contributes to normal neuronal functions.-
dc.language.isoen-
dc.subject.MESHAdenoviridae-
dc.subject.MESHAnimals-
dc.subject.MESHBase Sequence-
dc.subject.MESHBinding Sites-
dc.subject.MESHBlotting, Northern-
dc.subject.MESHBrain-Derived Neurotrophic Factor-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCyclic AMP-
dc.subject.MESHCyclic AMP Response Element-Binding Protein-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHElectrophoresis, Polyacrylamide Gel-
dc.subject.MESHExons-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGenes, Dominant-
dc.subject.MESHHippocampus-
dc.subject.MESHHumans-
dc.subject.MESHIntrons-
dc.subject.MESHLuciferases-
dc.subject.MESHMembrane Proteins-
dc.subject.MESHMitogen-Activated Protein Kinases-
dc.subject.MESHModels, Genetic-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHN-Methylaspartate-
dc.subject.MESHNeurons-
dc.subject.MESHPresenilin-1-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHProtein Binding-
dc.subject.MESHRNA, Messenger-
dc.subject.MESHRats-
dc.subject.MESHReceptors, Glutamate-
dc.subject.MESHReceptors, N-Methyl-D-Aspartate-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTime Factors-
dc.subject.MESHTranscription, Genetic-
dc.subject.MESHTransfection-
dc.subject.MESHTumor Cells, Cultured-
dc.titleActivated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.-
dc.typeArticle-
dc.identifier.pmid11116137-
dc.identifier.urlhttp://www.jbc.org/cgi/pmidlookup?view=long&pmid=11116137-
dc.contributor.affiliatedAuthor이, 영돈-
dc.type.localJournal Papers-
dc.identifier.doi10.1074/jbc.M006153200-
dc.citation.titleThe Journal of biological chemistry-
dc.citation.volume276-
dc.citation.number13-
dc.citation.date2001-
dc.citation.startPage9688-
dc.citation.endPage9698-
dc.identifier.bibliographicCitationThe Journal of biological chemistry, 276(13). : 9688-9698, 2001-
dc.identifier.eissn1083-351X-
dc.relation.journalidJ000219258-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse