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Potentiated necrosis of cultured cortical neurons by neurotrophins.

Authors
Koh, JY | Gwag, BJ  | Lobner, D | Choi, DW
Citation
Science (New York, N.Y.), 268(5210). : 573-575, 1995
Journal Title
Science (New York, N.Y.)
ISSN
0036-80751095-9203
Abstract
The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure to the calcium channel antagonist nimodipine. Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.
MeSH

PMID
7725105
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Ajou Authors
곽, 병주
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