repository
BROWSE
Cited 0 times in 
The cDNA cloning and ontogeny of mouse alpha-synuclein.
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hong, L | - |
| dc.contributor.author | Ko, HW | - |
| dc.contributor.author | Gwag, BJ | - |
| dc.contributor.author | Joe, E | - |
| dc.contributor.author | Lee, S | - |
| dc.contributor.author | Kim, YT | - |
| dc.contributor.author | Suh, YH | - |
| dc.date.accessioned | 2011-08-22T05:28:58Z | - |
| dc.date.available | 2011-08-22T05:28:58Z | - |
| dc.date.issued | 1998 | - |
| dc.identifier.issn | 0959-4965 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/3879 | - |
| dc.description.abstract | Alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. To investigate the role of alpha-synuclein in the brain, the cDNA clone encoding the mouse cognate of the human alpha-synuclein was isolated from a mouse brain cDNA library. The open reading frame coded for 140 amino acids that share 95% identity with human alpha-synuclein. Northern blot analysis showed that alpha-synuclein mRNA was primarily expressed in brain and spleen of adult mouse. In situ hybridization histochemistry revealed the highest expression of alpha-synuclein mRNA in the hippocampal formation and neocortex of the adult mouse. alpha-Synuclein mRNA expression in the brain was first observed in the hippocampus and neocortex on postnatal day 1. Levels of alpha-synuclein mRNA in these forebrain areas were nearly maximal at postnatal day 7 and remained relatively high until the adult stage. alpha-Synuclein mRNA was expressed in the liver transiently during embryogenesis. | - |
| dc.language.iso | en | - |
| dc.subject.MESH | Amino Acid Sequence | - |
| dc.subject.MESH | Animals | - |
| dc.subject.MESH | Base Sequence | - |
| dc.subject.MESH | Brain | - |
| dc.subject.MESH | Cloning, Molecular | - |
| dc.subject.MESH | DNA, Complementary | - |
| dc.subject.MESH | Genes, Dominant | - |
| dc.subject.MESH | Humans | - |
| dc.subject.MESH | Mice | - |
| dc.subject.MESH | Molecular Sequence Data | - |
| dc.subject.MESH | Mutation | - |
| dc.subject.MESH | Nerve Tissue Proteins | - |
| dc.subject.MESH | Parkinson Disease | - |
| dc.subject.MESH | Phenotype | - |
| dc.subject.MESH | RNA, Messenger | - |
| dc.subject.MESH | Sequence Homology, Nucleic Acid | - |
| dc.subject.MESH | Synucleins | - |
| dc.subject.MESH | alpha-Synuclein | - |
| dc.title | The cDNA cloning and ontogeny of mouse alpha-synuclein. | - |
| dc.type | Article | - |
| dc.identifier.pmid | 9601701 | - |
| dc.identifier.url | http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0959-4965&volume=9&issue=6&spage=1239 | - |
| dc.contributor.affiliatedAuthor | 곽, 병주 | - |
| dc.contributor.affiliatedAuthor | 조, 은혜 | - |
| dc.type.local | Journal Papers | - |
| dc.citation.title | Neuroreport | - |
| dc.citation.volume | 9 | - |
| dc.citation.number | 6 | - |
| dc.citation.date | 1998 | - |
| dc.citation.startPage | 1239 | - |
| dc.citation.endPage | 1243 | - |
| dc.identifier.bibliographicCitation | Neuroreport, 9(6). : 1239-1243, 1998 | - |
| dc.identifier.eissn | 1473-558X | - |
| dc.relation.journalid | J009594965 | - |
- Appears in Collections:
- Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
-
- License
