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A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages.

Authors
Lee, HJ  | Kim, NY | Jang, MK | Son, HJ | Kim, KM | Sohn, DH | Lee, SH  | Ryu, JH
Citation
Planta medica, 65(2). : 104-108, 1999
Journal Title
Planta medica
ISSN
0032-09431439-0221
Abstract
Nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (dehydrocostus lactone) isolated from the medicinal plant, Saussurea lappa, inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-alpha level in LPS-activated systems in vitro and in vivo. Thus, dehydrocostus lactone may be a possible candidate for the development of new drugs to treat endotoxemia accompanied by the overproduction of NO and TNF-alpha.
MeSH

DOI
10.1055/s-1999-13968
PMID
10193198
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Ajou Authors
이, 수환  |  이, 희주
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