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Correlation between IgA antibody and eosinophil cationic protein levels in induced sputum from asthmatic patients.

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dc.contributor.authorNahm, DH-
dc.contributor.authorPark, HS-
dc.date.accessioned2011-09-07-
dc.date.available2011-09-07-
dc.date.issued1997-
dc.identifier.issn0954-7894-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4055-
dc.description.abstractBACKGROUND: Eosinophils are known to be main effector cells in allergic inflammation and IgA antibody has been shown to be a potent stimulus for eosinophil degranulation in in vitro conditions.



OBJECTIVE: To evaluate the possible role of IgA antibodies on eosinophil degranulation in lower respiratory mucosa of asthmatics, we tried to find a correlation between total IgA and eosinophil cationic protein (ECP) levels in induced sputum from asthmatics.



METHODS: We measured total IgA and albumin levels by nephelometry, and eosinophil cationic protein levels by Pharmacia CAP system in induced sputum from 23 atopic asthmatics and 12 healthy controls.



RESULTS: IgA and albumin levels in induced sputum from asthmatics with sputum eosinophilia (sputum eosinophil count > or = 5% of 200 counted non-squamous cells) were significantly higher (P < 0.05) than those from controls. However, IgA and albumin levels in induced sputum from asthmatics without sputum eosinophilia were not significantly different with those from controls (P > 0.05). In induced sputum from asthmatics, ECP levels were significantly correlated with albumin (r = 0.44, P = 0.04) and IgA levels (r = 0.67, P = 0.002). ECP/albumin ratio was also significantly correlated with IgA/ albumin ratio (r = 0.61, P = 0.004).



CONCLUSION: Our results support the hypothesis that IgA antibodies in tracheobronchial secretion may be involved in eosinophil degranulation in asthma, and further study is needed to prove this hypothesis.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAlbumins-
dc.subject.MESHAsthma-
dc.subject.MESHBlood Proteins-
dc.subject.MESHEosinophil Granule Proteins-
dc.subject.MESHEosinophils-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin A-
dc.subject.MESHInflammation Mediators-
dc.subject.MESHMale-
dc.subject.MESHNephelometry and Turbidimetry-
dc.subject.MESHRibonucleases-
dc.subject.MESHSputum-
dc.titleCorrelation between IgA antibody and eosinophil cationic protein levels in induced sputum from asthmatic patients.-
dc.typeArticle-
dc.identifier.pmid9208189-
dc.contributor.affiliatedAuthor남, 동호-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.citation.titleClinical and experimental allergy-
dc.citation.volume27-
dc.citation.number6-
dc.citation.date1997-
dc.citation.startPage676-
dc.citation.endPage681-
dc.identifier.bibliographicCitationClinical and experimental allergy, 27(6). : 676-681, 1997-
dc.identifier.eissn1365-2222-
dc.relation.journalidJ009547894-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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