Cited 0 times in Scipus Cited Count

Attenuation of cortical neuronal apoptosis by gangliosides.

DC Field Value Language
dc.contributor.authorRyu, BR-
dc.contributor.authorChoi, DW-
dc.contributor.authorHartley, DM-
dc.contributor.authorCosta, E-
dc.contributor.authorJou, I-
dc.contributor.authorGwag, BJ-
dc.date.accessioned2011-09-07T02:16:57Z-
dc.date.available2011-09-07T02:16:57Z-
dc.date.issued1999-
dc.identifier.issn0022-3565-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4071-
dc.description.abstractAddition of the natural gangliosides monosialoganglioside (GM1), disialoganglioside, trisialoganglioside, or tetrasialoganglioside in the range of 10 to 100 microM, but not asialoganglioside lacking the sialic acid moiety, attenuated cortical neuronal apoptosis induced by serum deprivation, ionomycin, or cyclosporin A but not by protein kinase inhibitors (staurosporine, genistein, lavendustin A, or herbimycin A). Coaddition of 100 nM wortmannin, a selective inhibitor of phosphatidylinositol 3-kinase, but not 1 microM Go6976, a selective protein kinase C inhibitor, blocked the neuroprotective effect of GM1. In contrast to its antiapoptotic effect, GM1 at up to 200 microM did not attenuate cortical neuronal necrosis induced by exposure to the excitotoxins N-methyl-D-aspartate or kainate. Furthermore, GM1 increased the necrosis induced by oxidative stress (addition of Fe(2+) or buthionine sulfoximine). These data suggest that neuroprotective effects of natural gangliosides may preferentially reflect reduction of neuronal apoptosis rather than necrosis, and be mediated through mechanisms involving activation of phosphatidylinositol 3-kinase.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis-
dc.subject.MESHBrain-Derived Neurotrophic Factor-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCerebral Cortex-
dc.subject.MESHCulture Media, Serum-Free-
dc.subject.MESHCyclosporine-
dc.subject.MESHEnzyme Inhibitors-
dc.subject.MESHExcitatory Amino Acid Agonists-
dc.subject.MESHG(M1) Ganglioside-
dc.subject.MESHGangliosides-
dc.subject.MESHIonomycin-
dc.subject.MESHMice-
dc.subject.MESHN-Methylaspartate-
dc.subject.MESHNecrosis-
dc.subject.MESHNeurons-
dc.subject.MESHOxidative Stress-
dc.subject.MESHPhosphorylation-
dc.subject.MESHProtein Kinase Inhibitors-
dc.subject.MESHReceptor Protein-Tyrosine Kinases-
dc.titleAttenuation of cortical neuronal apoptosis by gangliosides.-
dc.typeArticle-
dc.identifier.pmid10411596-
dc.identifier.urlhttp://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=10411596-
dc.contributor.affiliatedAuthor주, 일로-
dc.contributor.affiliatedAuthor곽, 병주-
dc.type.localJournal Papers-
dc.citation.titleThe Journal of pharmacology and experimental therapeutics-
dc.citation.volume290-
dc.citation.number2-
dc.citation.date1999-
dc.citation.startPage811-
dc.citation.endPage816-
dc.identifier.bibliographicCitationThe Journal of pharmacology and experimental therapeutics, 290(2). : 811-816, 1999-
dc.identifier.eissn1521-0103-
dc.relation.journalidJ000223565-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse