A Case of Amylase Producing Small Cell Lung Cancer

Abstract

The majority of lung cancers associated with hyperamylasemia are adenocarcinomas.

Here we report an unusual case of a 54-year-old male patient who complained of

dyspnea, anterior chest wall discomfort and facial edema for one month, presenting with

a huge mediastinal mass and hyperamylasemia complicated by pericardial effusion

Histological evaluation of mediastinal mass revealed small cell carcinoma and

pericardium showed nonspecific inflammation with fibrosis. The serum amylase had an

electrophoretic mobility similar to that of salivary gland enzyme. There were no

evidence of a salivary or pancreatic causes of hyperamylasemia. After chemotherapy,

parenchymal lung lesions improved and hyperamylasemia disappeared. For the

mannagement of peracardial effusion a pericardial window was forms(i. We concluded

that the striking increase in serum amylase was due to the ectopic production of this

enzyme by the tumor.

종양세포에 의한 hyperamylasemia는 드물게 보고되고 있으며 주로 폐암에 의하고 조직형

은 선암으로 보고되어 있다. 이때 생성되는 아밀라제는 타액형으로 췌장질환에 의한 것과는

구별이 되며 hyperamylasemia에 의한 임상적인 증상은 없다. 저자등은 소세포성 폐암으로

진단받은 54세 남자 환자에서 혈청 아밀라제 농도가 상승되어 있음을 발견하고, 임상경과

및 검사결과 아밀라제를 분비하는 소세포성 폐암으로 진단하고 문헌 고찰과 함께 보고하는

바이다.