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Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma

Other Title
신세포암에서 Tissue Microarray를 이용하여 분석한 Caveolin-1 발현과 예후와의 연관성
Authors
원, 용연  | 주, 희재  | 조, 대성  | 서, 경식 | 안, 병철  | 김, 기훈 | 김, 세중
Citation
Korean journal of urology, 47(6). : 607-613, 2006
Journal Title
Korean journal of urology
ISSN
0494-4747
Abstract
Purpose: We investigated the relationship between the expression of caveolin-1, using a tissue microarray(TMA), and the prognosis of patients with renal cell carcinoma(RCC).
Materials and Methods: TMA sections of formalin-fixed, paraffin-embedded tissues of RCC from 82 patients, who had undergone radical nephrectomy, were stained immunohistochemically with specific antibodies against caveolin-1. The caveolin-1 immunostaining was semi-quantitatively estimated based on intensity. The expression pattern of caveolin-1 was compared with the clinicopathological variables.
Results: The expression of caveolin-1 was significantly correlated with tumor size(p=0.002), TNM stage(p<0.001), T stage(p=0.001), M stage (p=0.004), grade(p=0.028) and metastasis(p<0.001), and was also significantly higher in clear cell than non-clear cell RCC(p<0.001). The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression(p=0.001). Univariate analyses were able to identify all variables, including caveolin-1 expression as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that TNM stage, M stage and grade were independent prognostic factors. Caveolin-1 expression was not an independent factor.
Conclusions: The increased expression of caveolin-1 is associated with tumor size, stage, grade, metastasis and a worse prognosis in RCC, which suggests that caveolin-1 may be important in the progression of RCC.
Keywords

DOI
10.4111/kju.2006.47.6.607
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Ajou Authors
김, 세중  |  안, 병철  |  원, 용연  |  조, 대성  |  주, 희재
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