Gliosarcoma with Multiple Extracranial Metastasis

Abstract

The authors report a rare case of intracranial gliosarcoma associated with extracranial metastases. Computerized tomography and magnetic resonance imaging revealed a large mass involving the left sylvian fissure and a small round mass in the right frontal area. Chest X-ray showed a suspicious coin lesion; but a few small nodular densities, suspicious of metastasis, were noted on the chest CT. Grossly total resection of the tumor was achieved via CT-guided stereotactic fronto-temporal craniotomy. The supero-lateral part of the tumor was well demarcated from the surrounding non-neoplastic brain tissue, but at the medio-basal part, it was difficult to distinguish the tumor margin from the adjacent brain tissue. Histologically the tumor was diagnosed as gliosarcoma composed of two components, namely sarcomatous and glioblastomatous ones. The masses in the lung and breast were diagnosed to be a metastatic gliosarcoma by percutaneous needle biopsy. The patient received radiation therapy after surgery.