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Clinical Implication of Prostaglandin E2 Content in Lumbar Disc Disease

Other Title
추간판내 Prostaglandin E2 양의 임상적 의의
Authors
김, 형석 | 조, 기홍  | 김, 기용 | 안, 영환  | 안, 영민 | 윤, 수한  | 조, 경기
Citation
Journal of Korean Neurosurgical Society, 29(10). : 1340-1344, 2000
Journal Title
Journal of Korean Neurosurgical Society
ISSN
1225-8245
Abstract
Objective: A prospective biochemical assay of prostaglandin E2 content in symptomatic lumbar disc materials was done in order to clarify the pathogenesis of lumbar radiculopathy.
Patients and Methods: Forty-eight disc specimens were purified by a standard solid-phase extraction procedure and analyzed by an enzymelinked immunosorbent assay for prostaglandin E2. Clinical and anatomic correlations were evaluated with analysis of variance and t-test.
Results: Acute herniated lumbar disc diseases tended to be associated with a higher prostaglandin E2 content than degenerative lumbar disc disease. Sequestered discs tended to be associated with a higher prostaglandin E2 content than extruded discs, which also showed higher prostaglandin E2 content than protruded ones. A sciatica and positive straight leg raising test appeared to be associated with a higher prostaglandin E2 content than a negative test.
Conclusion: This result suggests that the level of prostaglandin E2 would be correlated with clinical symptom and sign in the inflammatory process of lumbar disc herniation.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
Ajou Authors
안, 영환  |  윤, 수한  |  조, 경기  |  조, 기홍
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