다양한 피부질환에서 에스트로겐 수용체와 프로게스테론 수용체의 발현

Abstract

BACKGROUND: Estrogen receptor(ER) and progesterone receptor(PR) has identified in normal target cells and their neoplastic counterparts respectively, especially in the tumors of breast and female genital tract. Presence of ER/PR suggests that these normal target cells and tumor cells are regulated by estrogen or progesterone. The exact mechanism of hormones which affect skin is unclear even though a clinical findings suggest that the skin can be a target tissue for female sex hormones. OBJECTIVE: To evaluate the relation between the female sex hormones and skin diseases, expression patterns of ER/PR in tissues of normal skin and various skin diseases were studied. METHODS : Immunohistochemical analyses of ER and PR were performed on the paraffin-embedded tissue sections of various skin diseases using anti-ER and anti-PR monoclonal antibodies with an avidin-biotin peroxidase complex procedure. RESULTS: Suprabasal keratinocytes from samples of psoriasis, keratosis palmaris et plantaris, verruca vulgaris, allergic contact dermatitis, chronic eczema, drug eruption, erythema multiforme, dermatofibroma, granuloma pyogenicum, keratoacanthoma, malignant melanoma, squamous cell carcinoma, and syringoma were positively stained only for PR, while those of erythema nodosum, basal cell epithelioma, epidermal nevus, and seborrheic keratosis were negatively stained for both ER and PR immunostainings. All the samples stained positively to PR showed cytoplasmic immunoreactivity for PR, but age/sex did not influence the PR immunoreactivity. CONCLUSION: This study showed that PR immunoreactivity is increased in diseases related to inflammatory processes, proliferation or squamous differentiation of keratinocytes. Further investigation of the nature of PR immunoreactivity and role of progesterone in vivo and in vitro may provide important insights into the mechanisms that control hormone responsiveness.