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Synergistic Effects of Vsncomycin, Penicillin, and Gentamicin against Vancomycin-Resistant Enterococci

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dc.contributor.author이, 위교-
dc.contributor.author이, 선민-
dc.contributor.author곽, 연식-
dc.date.accessioned2011-12-21T01:19:57Z-
dc.date.available2011-12-21T01:19:57Z-
dc.date.issued1997-
dc.identifier.issn1225-7850-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4958-
dc.description.abstractBackground : Because of the resistance that enterococci aiready exhibit to a variety of

antimicrobial agents, the emergence of vancomycin resistance is troublesome. The

combined regimes may offer a treatment for patients infected with vancomycin-resistant

enterooocci. We examined the antibiotic synergistic killing of clinical isolates of

vancomycih-resistant enterococci belonging to genotypic resistance classes A, B, and C.

Methods : Nine strains of vancomycin-resistant enterococci and 2 strains of

vancomycin-susceptible enterococci were utilized in this study. MICs were determined

by agar dilution method. Synergistic inhibition of growth was assessed by addition

vancomycin(8㎍/mL), penicillin(2㎍/mL), gentamicin(1㎍/mL), or combinations of these

antibiotics to cultures in the early logarlthaic phase of growth. Synergy was defined as

a decrease in CFU/mL by at least 2 log10 after 24 h compared with the effect of the

most active single agent.

Results : Vancomycin-penicillin-gentamicini and vancomycin-penicillin resulted in 2 or

more logs of killing above that the most effective single agent for all VanA and VanB

strains. All VanC strains were resistant to any antibiotics combination.

Conclusion : Triple combination therapy arid vancomycin plus penicillin regimen may

be effective for the treatment of infections caused by vancomycin-resistant enterococci

belonging to genotypic classes VanA and VanB. Further studios are needed for the new

therapeutic regimen agaist VanC strains.
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dc.language.isoko-
dc.titleSynergistic Effects of Vsncomycin, Penicillin, and Gentamicin against Vancomycin-Resistant Enterococci-
dc.title.alternativeVancomycin 내성 장구균에 대한 Vancomycin, Penicillin 및 Gentamicin의 병용효과-
dc.typeArticle-
dc.identifier.urlhttp://www.icjournal.org/articles/list_ava.php?code=chemo&year=1997&vol=15&page=135&no=2-
dc.subject.keywordVancomycin-resistant enterococci-
dc.subject.keywordVancomycin-
dc.subject.keywordPenicillin-
dc.subject.keywordGentamicin-
dc.type.localJournal Papers-
dc.citation.titleJournal of the Korean Society for Chemotherapy-
dc.citation.volume15-
dc.citation.number2-
dc.citation.date1997-
dc.citation.startPage243-
dc.citation.endPage250-
dc.identifier.bibliographicCitationJournal of the Korean Society for Chemotherapy, 15(2). : 243-250, 1997-
dc.relation.journalidJ012257850-
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Journal Papers > School of Medicine / Graduate School of Medicine > Unclassified
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