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Experience of Simplified Protocols in In-Vitro Fertilization and Embryo Transfer Program
DC Field | Value | Language |
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dc.contributor.author | 권, 혁찬 | - |
dc.contributor.author | 황, 경주 | - |
dc.contributor.author | 양, 현원 | - |
dc.contributor.author | 유, 정현 | - |
dc.contributor.author | 홍, 순정 | - |
dc.contributor.author | 박, 지영 | - |
dc.contributor.author | 윤, 인자 | - |
dc.contributor.author | 김, 동민 | - |
dc.contributor.author | 박, 찬일 | - |
dc.contributor.author | 김, 행수 | - |
dc.contributor.author | 오, 기석 | - |
dc.date.accessioned | 2012-01-30T01:37:51Z | - |
dc.date.available | 2012-01-30T01:37:51Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0494-4755 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/5390 | - |
dc.description.abstract | During the past few years much effort has been put into simplifying the clinical man-agement of in-vitro fertilization/embryo transfer cycles. One important step was the intro-duction of transvaginal ultrasound-guided oocyte collection, as previously described. This study describes further simplifications in the clinical management of ovarian stimulation and luteal support, and in-vitro fertilization procedure. During the period from October 1994 to September 1995, two major simplification steps were introduced. All cycles were administe-red with a gonadotrophin-releasing hormone agonist according to a long or short protocol preventing premature LH surge. During period Ⅰ(Group Ⅰ, n=62 cycles), closer monitoring by several pelvic ultrasound scans and serum oestradiol was used for monitoring the ovarian stimulation;HTF media with fetal cord serum was used for insemination, growth and tran-sfer media in IVF-ET procedure;progesterine in oil was daily used by intramuscular injec-tion for luteal support. During period Ⅱ(Group Ⅱ-Ⅰ, n=71 cycles), only several ultrasound scans were used for monitoring the ovarian cycle;Medi-cult IVF media containing synthetic serum replacement was used for insemination, growth and transfer media; Progesterine in oil was used daily by intramuscular injection for luteal support. During period Ⅲ(Group Ⅱ-Ⅱ, n=16 cycles), further simplification of the clinical management was introduced by using a intravaginal micronized progesterone(Utrogestan) for luteal support. Retrospective analysis between Group Ⅰ and Group Ⅱ showed no differences in the number of oocyte(13.2±0.8/14.6±1.0), fertilization rate(71.5 %/60.7 %), cleavage rate(63.6 %/57.9 %), number of embryos transfered(5.0±0.5/4.5±0.5). Ongoing pregnancy rates obta ined from the three groups(Group Ⅰ, Group Ⅱ-1, Group Ⅱ-Ⅱ) were 25.8 %, 25 % and 40 %, respectively(p=ns). But introduction of minimal monitoring gave a significant reduction in the average number of US measurements in the simplified groups(Group Ⅱ) compared with the group using the conventional monitoring protocol(Group Ⅰ)(3.8±1.0/8.7±2.8, p<0.05). In the above groups, five patients developed severe OHSS but there was no differenc e in the distribution. Conclusively, simplified protocols including minimal follicle monitoring only by US, IVF-ET with Medi-cult IVF media containing synthetic serum replacement and the luteal support with intravaginal micronized progesterone gave a increased efficacy of the clinical phase of IVF treatment without a reduction in the success rate. | - |
dc.format | text/plain | - |
dc.language.iso | ko | - |
dc.title | Experience of Simplified Protocols in In-Vitro Fertilization and Embryo Transfer Program | - |
dc.title.alternative | 단순화된 체외수정 및 배아이식술의 경험 | - |
dc.type | Article | - |
dc.subject.keyword | IVF-ET | - |
dc.subject.keyword | GnRH agonist | - |
dc.subject.keyword | simplification | - |
dc.subject.keyword | serum-free culture media | - |
dc.subject.keyword | synthetic serum replacement | - |
dc.subject.keyword | micronized progesterone | - |
dc.contributor.affiliatedAuthor | 권, 혁찬 | - |
dc.contributor.affiliatedAuthor | 황, 경주 | - |
dc.contributor.affiliatedAuthor | 김, 행수 | - |
dc.contributor.affiliatedAuthor | 오, 기석 | - |
dc.type.local | Journal Papers | - |
dc.citation.title | Korean journal of obstetrics and gynecology | - |
dc.citation.volume | 40 | - |
dc.citation.number | 10 | - |
dc.citation.date | 1997 | - |
dc.citation.startPage | 2119 | - |
dc.citation.endPage | 2129 | - |
dc.identifier.bibliographicCitation | Korean journal of obstetrics and gynecology, 40(10). : 2119-2129, 1997 | - |
dc.relation.journalid | J004944755 | - |
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