Cited 0 times in Scipus Cited Count

Experience of Simplified Protocols in In-Vitro Fertilization and Embryo Transfer Program

DC Field Value Language
dc.contributor.author권, 혁찬-
dc.contributor.author황, 경주-
dc.contributor.author양, 현원-
dc.contributor.author유, 정현-
dc.contributor.author홍, 순정-
dc.contributor.author박, 지영-
dc.contributor.author윤, 인자-
dc.contributor.author김, 동민-
dc.contributor.author박, 찬일-
dc.contributor.author김, 행수-
dc.contributor.author오, 기석-
dc.date.accessioned2012-01-30T01:37:51Z-
dc.date.available2012-01-30T01:37:51Z-
dc.date.issued1997-
dc.identifier.issn0494-4755-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5390-
dc.description.abstractDuring the past few years much effort has been put into simplifying the clinical man-agement of in-vitro fertilization/embryo transfer cycles. One important step was the intro-duction of transvaginal ultrasound-guided oocyte collection, as previously described. This study describes further simplifications in the clinical management of ovarian stimulation and luteal support, and in-vitro fertilization procedure. During the period from October 1994 to September 1995, two major simplification steps were introduced. All cycles were administe-red with a gonadotrophin-releasing hormone agonist according to a long or short protocol preventing premature LH surge. During period Ⅰ(Group Ⅰ, n=62 cycles), closer monitoring by several pelvic ultrasound scans and serum oestradiol was used for monitoring the ovarian stimulation;HTF media with fetal cord serum was used for insemination, growth and tran-sfer media in IVF-ET procedure;progesterine in oil was daily used by intramuscular injec-tion for luteal support. During period Ⅱ(Group Ⅱ-Ⅰ, n=71 cycles), only several ultrasound scans were used for monitoring the ovarian cycle;Medi-cult IVF media containing synthetic serum replacement was used for insemination, growth and transfer media; Progesterine in oil was used daily by intramuscular injection for luteal support. During period Ⅲ(Group Ⅱ-Ⅱ, n=16 cycles), further simplification of the clinical management was introduced by using a intravaginal micronized progesterone(Utrogestan) for luteal support. Retrospective analysis between Group Ⅰ and Group Ⅱ showed no differences in the number of oocyte(13.2±0.8/14.6±1.0), fertilization rate(71.5 %/60.7 %), cleavage rate(63.6 %/57.9 %), number of embryos transfered(5.0±0.5/4.5±0.5). Ongoing pregnancy rates obta ined from the three groups(Group Ⅰ, Group Ⅱ-1, Group Ⅱ-Ⅱ) were 25.8 %, 25 % and 40 %, respectively(p=ns). But introduction of minimal monitoring gave a significant reduction in the average number of US measurements in the simplified groups(Group Ⅱ) compared with the group using the conventional monitoring protocol(Group Ⅰ)(3.8±1.0/8.7±2.8, p<0.05). In the above groups, five patients developed severe OHSS but there was no differenc e in the distribution. Conclusively, simplified protocols including minimal follicle monitoring only by US, IVF-ET with Medi-cult IVF media containing synthetic serum replacement and the luteal support with intravaginal micronized progesterone gave a increased efficacy of the clinical phase of IVF treatment without a reduction in the success rate.-
dc.formattext/plain-
dc.language.isoko-
dc.titleExperience of Simplified Protocols in In-Vitro Fertilization and Embryo Transfer Program-
dc.title.alternative단순화된 체외수정 및 배아이식술의 경험-
dc.typeArticle-
dc.subject.keywordIVF-ET-
dc.subject.keywordGnRH agonist-
dc.subject.keywordsimplification-
dc.subject.keywordserum-free culture media-
dc.subject.keywordsynthetic serum replacement-
dc.subject.keywordmicronized progesterone-
dc.contributor.affiliatedAuthor권, 혁찬-
dc.contributor.affiliatedAuthor황, 경주-
dc.contributor.affiliatedAuthor김, 행수-
dc.contributor.affiliatedAuthor오, 기석-
dc.type.localJournal Papers-
dc.citation.titleKorean journal of obstetrics and gynecology-
dc.citation.volume40-
dc.citation.number10-
dc.citation.date1997-
dc.citation.startPage2119-
dc.citation.endPage2129-
dc.identifier.bibliographicCitationKorean journal of obstetrics and gynecology, 40(10). : 2119-2129, 1997-
dc.relation.journalidJ004944755-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse