We experienced a 4-month-old boy presenting with fever and painful scrotal swelling. Diagnostic work-up showed the presence of urinary tract infection and concurrent acute epididymitis. On the voiding cysttourethrography, vesicoureteral reflux and urinary reflux throughthe ejaculatory duct and the seminal vesicle were detected without obvious urethral obstruc-tion. In general, urinary reflux into the seminal vesicle can take place with obstructivelesions of the urethra and may cause epididymitis in infants. We report a case of urinary reflux without urethral obstruction with a brief review of related literatures.