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Differences in tumor characteristics and prognosis in newly diagnosed Ta, T1 urothelial carcinoma of bladder according to patient age.
DC Field | Value | Language |
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dc.contributor.author | Cho, KS | - |
dc.contributor.author | Hwang, TK | - |
dc.contributor.author | Kim, BW | - |
dc.contributor.author | Yoon, DK | - |
dc.contributor.author | Chang, SG | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Park, JY | - |
dc.contributor.author | Cheon, J | - |
dc.contributor.author | Sung, GT | - |
dc.contributor.author | Hong, SJ | - |
dc.date.accessioned | 2010-12-14T05:05:25Z | - |
dc.date.available | 2010-12-14T05:05:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0090-4295 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/567 | - |
dc.description.abstract | OBJECTIVES: To evaluate the differences in tumor characteristics and prognosis according to age at presentation in patients with newly diagnosed Stage Ta, T1 urothelial carcinoma of the bladder.
METHODS: From 1998 to 2002, 1587 patients with newly diagnosed nonmuscle-invasive bladder cancer treated with transurethral resection were enrolled in this study. The median age was 63 years (range 21-98), and the median follow-up duration was 44 months (range 12-97). The study cohort was subdivided into 3 age groups: age < 60 years (group 1, n = 614), age > or = 60 but < 70 years (group 2, n = 566), and age > or = 70 years (group 3, n = 398). RESULTS: Comparing the clinical and pathologic characteristics, the tumor size (chi(2)(trend) = 4.01, P = .045), multiplicity (chi(2)(trend) = 14.50, P < .001), T category (chi(2)(trend) = 17.11, P < .001), and tumor grade (chi(2)(trend) = 31.36, P < .001) tended to increase in the older age groups. The presence of carcinoma in situ and squamous differentiation, however, did not differ among the age groups (P > .05). The 5-year recurrence-free probability was 63.6%, 52.1%, and 43.9% for groups 1, 2, and 3, respectively (P < .001). The 5-year progression-free probability was 95.7%, 91.1%, and 84.2% for groups 1, 2, and 3, respectively (P < .001). CONCLUSIONS: Stage Ta, T1 bladder urothelial carcinoma in the younger patients tended to be smaller, have fewer lesions, be less invasive, and have a more favorable tumor grade at the initial presentation. Furthermore, younger patients appeared to have a more favorable prognosis than older patients. | - |
dc.language.iso | en | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Transitional Cell | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Urinary Bladder Neoplasms | - |
dc.title | Differences in tumor characteristics and prognosis in newly diagnosed Ta, T1 urothelial carcinoma of bladder according to patient age. | - |
dc.type | Article | - |
dc.identifier.pmid | 19195693 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0090-4295(08)01808-6 | - |
dc.contributor.affiliatedAuthor | 김, 세중 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.urology.2008.10.038 | - |
dc.citation.title | Urology | - |
dc.citation.volume | 73 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 828 | - |
dc.citation.endPage | 832 | - |
dc.identifier.bibliographicCitation | Urology, 73(4). : 828-832, 2009 | - |
dc.identifier.eissn | 1527-9995 | - |
dc.relation.journalid | J000904295 | - |
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