Changes of serum neutrophil chemotactic activity(NCA) and myeloperoxidase (MPO) level following lysine-aspirin(L-ASA) bronchoprovocation test in aspirin-sensitive asthmatic patients

Abstract

Background : There have been few reports suggesting involvement of mast cell and neutrophil to induce bronchoconstriction in aspirin-sensitive asthma. Objective : To evaluate mast cell and neutrophil activation in pathogenesis of aspirin-sensitive asthma. Material and methods : We observed changes of serum NCA and MPO levels during L-ASA bronchoprovocation test in 14 subjects with aspirin-sensitive asthma. Results : Serum NCA was significantly increased at 30 min(p=0.01) after the inhalation of L-ASA and then, no significant changes were noted at 240 min(p=0.14). NCA was significantly higher in subjects with late asthmatic responses than in those without it(p=0.04). Serum MPO level tended to increase at, 30 min with no statistical significance(p=0.08), and then it significantly decreased at 240 min (p=0.05). There was no significant correlation between serum NCA and MPO level(r=0.22, p=0.58). Conclusion : These results support the view that NCA derived from mast cell may contribute to neutrophil recruitment into the airway in aspirin-sensitive asthmatic patients.