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Serum Specific IgE to Staphylococcal Superantigens in Sera of ASA-intolerant Asthma
DC Field | Value | Language |
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dc.contributor.author | 오, 정미 | - |
dc.contributor.author | 김, 승현 | - |
dc.contributor.author | 윤, 성호 | - |
dc.contributor.author | 김, 상하 | - |
dc.contributor.author | 서, 창희 | - |
dc.contributor.author | 남, 동호 | - |
dc.contributor.author | 박, 해심 | - |
dc.date.accessioned | 2012-02-22T04:53:03Z | - |
dc.date.available | 2012-02-22T04:53:03Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1226-8739 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/5765 | - |
dc.description.abstract | Objective : Several studies suggest that serum total IgE (tIgE) level tended to be higher in ASA-intolerant asthma (AIA) than in other types of non-atopic asthma, whether they are atopics or non-atopics. A pathogenic role of superantigens was suggested in inflammatory responses of upper respiratory allergy with increased IgE production. To investigate a role of staphylococcal superantigens in AIA, we measured serum specific IgE level to three staphylococcal superantigens (SEA, SEB, TSST-1) in the sera of ASA-tolerant asthma (AIA), ASA tolerant asthma (ATA) patients, and normal control (NC).
METHOD : Fifty-six AIA patients showing positive responses on L-ASA bronchoprovocation test, 40 ATA, and 30 non-atopic healty controls were enrolled. Serum specific IgE to three staphylococcal superantigens were measured by CAP system (Pharmacia, Uppsala, Sweden). RESULT : The prevalences of specific IgE to each superantigens were highest in AIA, followed by ATA and NC. Significanct differences were noted in the prevalence of IgE to TSST-1 and SEB between AIA and NC (P<0.05, respectively). Serum total IgE levels were significantly higher in superantigen-positive AIA patients (P<0.05, respectively). Furthermore, in non-atopic AIA patients, those with TSST-1 specific IgE had significantly higher total IgE levels (P<0.05, respectively). There were no correlations between superantigen-specific IgE level and sex, atopy status or presence of urticaria. Significant correlations were found between specific IgE to SEB or TSST-1 and serum total IgE level (r=0.42, 0.30, P<0.05), and specific IgE to TSST-1 and PC20 methacholine (r=-0.36, P<0.05). No significant correlations were found between superantigen-specific IgE and serum soluble CD30 level or cumulative dose of L-ASA inhaled. CONCLUSION: Superantigen may contribute to increase in serum total IgE level, in particular, significant association with TSST-1 was noted in non-atopic AIA patients. Further studies will be needed to investigate how they contribute to AIA pathophysiology. | en |
dc.format | application/pdf | - |
dc.language.iso | ko | - |
dc.title | Serum Specific IgE to Staphylococcal Superantigens in Sera of ASA-intolerant Asthma | - |
dc.title.alternative | 아스피린 불내성 천식환자에서 포도상구균에 대한 혈청 특이 IgE 항체 측정 | - |
dc.type | Article | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001150534 | - |
dc.subject.keyword | Superantigen | - |
dc.subject.keyword | Staphylococcus aureus | - |
dc.subject.keyword | ASA intolerant asthma | - |
dc.contributor.affiliatedAuthor | 서, 창희 | - |
dc.contributor.affiliatedAuthor | 남, 동호 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.citation.title | Korean journal of asthma, allergy and clinical immunology | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2004 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 252 | - |
dc.identifier.bibliographicCitation | Korean journal of asthma, allergy and clinical immunology, 24(2). : 247-252, 2004 | - |
dc.relation.journalid | J112268739 | - |
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