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Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia.

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dc.contributor.authorLee, JH-
dc.contributor.authorOh, YM-
dc.contributor.authorSeo, JB-
dc.contributor.authorLee, YK-
dc.contributor.authorKim, WJ-
dc.contributor.authorSheen, SS-
dc.contributor.authorKim, TH-
dc.contributor.authorKim, EK-
dc.contributor.authorLee, JS-
dc.contributor.authorHuh, JW-
dc.contributor.authorLim, SY-
dc.contributor.authorYoon, HI-
dc.contributor.authorShin, TR-
dc.contributor.authorLee, SM-
dc.contributor.authorLee, SY-
dc.contributor.authorLee, SD-
dc.date.accessioned2012-04-23T01:58:59Z-
dc.date.available2012-04-23T01:58:59Z-
dc.date.issued2011-
dc.identifier.issn1027-3719-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6477-
dc.description.abstractBACKGROUND: Chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension and cor pulmonale, which are predictors of mortality.



OBJECTIVE: To identify predictors of increased pulmonary artery pressure (PAP) in COPD patients without resting hypoxaemia, and to characterise COPD patients with increased PAP.



DESIGN: A study of 117 COPD patients from the Korean Obstructive Lung Disease (KOLD) cohort who had measurable tricuspid regurgitant flow under transthoracic Doppler echocardiography and no resting hypoxaemia.



RESULTS: The mean patient age was 67 years. Mean forced expiratory volume in 1 second (FEV(1)) was 47% predicted, mean haemoglobin (Hb) concentration was 145 g/l and mean systolic PAP (sPAP) was 33 mmHg. Multiple linear regression analysis showed that Hb was the only factor independently associated with sPAP (beta = -1.752, P = 0.005). Cluster analysis using FEV(1)% predicted, sPAP and Hb concentration as variables indicated three patient clusters: Cluster 1 (n = 36; mean FEV(1) 44% predicted, mean sPAP 39 mmHg, mean Hb 132 g/l), Cluster 2 (n = 45; FEV(1) 35% predicted, sPAP 31 mmHg, Hb 154 g/l), and Cluster 3 (n = 36; FEV(1) 65% predicted, sPAP 29 mmHg, Hb 148 g/l).



CONCLUSION: Elevated PAP was linked to low haemoglobin levels in COPD without resting hypoxaemia.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnemia-
dc.subject.MESHAnoxia-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHemoglobins-
dc.subject.MESHHumans-
dc.subject.MESHHypertension, Pulmonary-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulmonary Artery-
dc.subject.MESHPulmonary Disease, Chronic Obstructive-
dc.subject.MESHQuestionnaires-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHSpirometry-
dc.titlePulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia.-
dc.typeArticle-
dc.identifier.pmid21575307-
dc.identifier.urlhttp://openurl.ingenta.com/content/nlm?genre=article&issn=1027-3719&volume=15&issue=6&spage=830&aulast=Lee-
dc.contributor.affiliatedAuthor신, 승수-
dc.type.localJournal Papers-
dc.identifier.doi10.5588/ijtld.10.0598-
dc.citation.titleThe international journal of tuberculosis and lung disease-
dc.citation.volume15-
dc.citation.number6-
dc.citation.date2011-
dc.citation.startPage830-
dc.citation.endPage837-
dc.identifier.bibliographicCitationThe international journal of tuberculosis and lung disease, 15(6). : 830-837, 2011-
dc.identifier.eissn1815-7920-
dc.relation.journalidJ010273719-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
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