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Prognostic significance of human epididymis protein 4 in epithelial ovarian cancer.

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dc.contributor.authorPaek, J-
dc.contributor.authorLee, SH-
dc.contributor.authorYim, GW-
dc.contributor.authorLee, M-
dc.contributor.authorKim, YJ-
dc.contributor.authorNam, EJ-
dc.contributor.authorKim, SW-
dc.contributor.authorKim, YT-
dc.date.accessioned2012-05-08T07:02:19Z-
dc.date.available2012-05-08T07:02:19Z-
dc.date.issued2011-
dc.identifier.issn0301-2115-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6856-
dc.description.abstractOBJECTIVE: The purpose of this study was to evaluate the prognostic significance of serum human epididymis protein 4 (HE4) level in patients with epithelial ovarian cancer.



STUDY DESIGN: A total of 78 women diagnosed with a pelvic mass and operated on in our institute comprised our cohort. Forty-five of these were diagnosed with epithelial ovarian cancer and treated with debulking surgery, followed by taxane and platinum-based chemotherapy as clinically indicated. Preoperatively obtained serum samples were analyzed for levels of HE4 and CA125.



RESULTS: The elevated serum HE4 level was related to advanced stage and serous type of cancer. The median duration of the follow-up was 35.1 months. In advanced stage, the median progression-free survival (PFS) of patients with elevated serum HE4 levels was 20.1 months (95% CI, 15.7-24.6 months), whereas that of patients with normal serum HE4 level was 24.2 months (95% CI, 13.9-34.6 months) (p=0.029). Independent predictors for PFS in patients with advanced stage EOC included serum HE4 level (hazard ratio 2.24; 95% CI, 1.14 to 6.84; p=0.048).



CONCLUSIONS: Our results demonstrated that an elevated serum HE4 level was related to the advanced stage of epithelial ovarian cancer. An elevated serum level of HE4 is a poor prognostic factor for PFS in patients with epithelial ovarian cancer who were treated with debulking surgery and adjuvant taxane and platinum-based chemotherapy. The serum HE4 level is a promising indicator for the progression of cancer as well as a biomarker for the detection of epithelial ovarian cancer.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHCA-125 Antigen-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeoplasms, Glandular and Epithelial-
dc.subject.MESHOvarian Neoplasms-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProteins-
dc.subject.MESHTumor Markers, Biological-
dc.titlePrognostic significance of human epididymis protein 4 in epithelial ovarian cancer.-
dc.typeArticle-
dc.identifier.pmid21683503-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0301-2115(11)00316-2-
dc.contributor.affiliatedAuthor백, 지흠-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ejogrb.2011.05.021-
dc.citation.titleEuropean journal of obstetrics, gynecology, and reproductive biology-
dc.citation.volume158-
dc.citation.number2-
dc.citation.date2011-
dc.citation.startPage338-
dc.citation.endPage342-
dc.identifier.bibliographicCitationEuropean journal of obstetrics, gynecology, and reproductive biology, 158(2). : 338-342, 2011-
dc.identifier.eissn1872-7654-
dc.relation.journalidJ003012115-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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