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Association of TNF-alpha promoter polymorphisms with aspirin-induced urticaria.
DC Field | Value | Language |
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dc.contributor.author | Choi, JH | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Cho, BY | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Suh, CH | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-20T06:34:03Z | - |
dc.date.available | 2010-12-20T06:34:03Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0269-4727 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/709 | - |
dc.description.abstract | OBJECTIVE: Although the pathogenesis of aspirin-induced urticaria (AIU) is not fully understood, mast cell activation has been noted in patients with AIU. Tumour necrosis factor (TNF)-alpha, a potent pro-inflammatory cytokine, is released by human skin mast cells and other inflammatory cells in patients with urticaria. To investigate the role of TNF-alpha promoter polymorphisms in the development of AIU, we performed an association study of TNF-alpha promoter polymorphisms with AIU phenotype.
METHODS: Two hundred thirty-nine patients with AIU consisting of 120 patients with aspirin intolerant chronic urticaria (AICU) and 119 with aspirin-intolerant acute urticaria (AIAU), and 524 normal controls were enrolled. AIU was confirmed by oral aspirin challenge test. Five SNPs in the TNF-alpha gene (-1031T>C, -863C>A, -857C>T, -308G>A, -238G>A) were genotyped by a single-base extension method. Haplotype analyses were done. RESULTS: The genotype frequencies of TNF-1031T>C and TNF-863C>A were significantly higher in the AIU patients than in the normal controls in both co-dominant (P = 0.014, P = 0.007) and dominant (P = 0.007, P = 0.004) models. The frequency of TNF-ht2[CACGG] containing a genotype in the AIU group was significantly higher in the normal controls with both co-dominant (P = 0.004, Pc = 0.02) and dominant models (P = 0.002, Pc = 0.01). CONCLUSIONS: These findings suggest that the two promoter polymorphisms of TNF-alpha at -1031T>C and -863C>A may contribute to the development of AIU. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Skin Tests | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha | - |
dc.subject.MESH | Urticaria | - |
dc.title | Association of TNF-alpha promoter polymorphisms with aspirin-induced urticaria. | - |
dc.type | Article | - |
dc.identifier.pmid | 19250144 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-4727&date=2009&volume=34&issue=2&spage=231 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 서, 창희 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/j.1365-2710.2008.00979.x | - |
dc.citation.title | Journal of clinical pharmacy and therapeutics | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 231 | - |
dc.citation.endPage | 238 | - |
dc.identifier.bibliographicCitation | Journal of clinical pharmacy and therapeutics, 34(2). : 231-238, 2009 | - |
dc.identifier.eissn | 1365-2710 | - |
dc.relation.journalid | J002694727 | - |
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