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Overdose rate of drugs requiring renal dose adjustment: data analysis of 4 years prescriptions at a tertiary teaching hospital.
DC Field | Value | Language |
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dc.contributor.author | Sheen, SS | - |
dc.contributor.author | Choi, JE | - |
dc.contributor.author | Park, RW | - |
dc.contributor.author | Kim, EY | - |
dc.contributor.author | Lee, YH | - |
dc.contributor.author | Kang, UG | - |
dc.date.accessioned | 2010-12-21T02:08:23Z | - |
dc.date.available | 2010-12-21T02:08:23Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0884-8734 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/719 | - |
dc.description.abstract | OBJECTIVE: To determine the overdose rate of drugs that require renal dose adjustment and factors related with overdose.
SUBJECTS: Total of 23,635,210 records of prescriptions and laboratory data of inpatients at a tertiary teaching hospital for the period from January 2002 to December 2005. METHODS: A clinical data mart was constructed. A knowledge base containing dose adjusting information about 56 drugs was built. One day dose was compared to the reference dose adjusted to the patient's renal function. RESULTS: Considering the patient's renal function, 5.3% of drug doses were excessive. The overdose rate in the patients with moderate to severe renal insufficiency was 28.2%. Only 25% of physicians were responsible for 50.6% of the overdoses. Of 56 drugs studied, 10 drugs, including ranitidine, amoxicillin, and piperacillin/tazobactam, were involved in 85.4% of the overdoses. The physicians with high overdose rate had patients with more impaired renal function (correlation coefficient = 0.192, P < .001). There were negative correlation between clinical experiences of physician and overdose rate (correlation coefficient = -0.221, P < .001) and workload of prescription (correlation coefficient = -0.446, P < .001), when excluding interns from the analyses. There was positive correlation between workload of prescription and overdose rate (correlation coefficient = 0.361, P < .001). CONCLUSION: A clinical data mart was useful to analyze the vast amount of electronic hospital data. Drug overdose is quite common among inpatients with renal insufficiency. Only a few drugs are responsible for most of drug overdoses. The physicians' clinical experience, workload of prescriptions, and patients' renal function are correlated with drug overdose. | - |
dc.language.iso | en | - |
dc.subject.MESH | Clinical Competence | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Hospital Information Systems | - |
dc.subject.MESH | Hospitals, Teaching | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Function Tests | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Medical Audit | - |
dc.subject.MESH | Medical Order Entry Systems | - |
dc.subject.MESH | Medication Errors | - |
dc.subject.MESH | Overdose | - |
dc.subject.MESH | Renal Insufficiency | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Overdose rate of drugs requiring renal dose adjustment: data analysis of 4 years prescriptions at a tertiary teaching hospital. | - |
dc.type | Article | - |
dc.identifier.pmid | 18373140 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359525/ | - |
dc.contributor.affiliatedAuthor | 신, 승수 | - |
dc.contributor.affiliatedAuthor | 박, 래웅 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s11606-007-0336-8 | - |
dc.citation.title | Journal of general internal medicine | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 423 | - |
dc.citation.endPage | 428 | - |
dc.identifier.bibliographicCitation | Journal of general internal medicine, 23(4). : 423-428, 2008 | - |
dc.identifier.eissn | 1525-1497 | - |
dc.relation.journalid | J008848734 | - |
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