Cited 0 times in
Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hur, GY | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Park, SM | - |
dc.contributor.author | Ye, YM | - |
dc.contributor.author | Kim, CW | - |
dc.contributor.author | Jang, AS | - |
dc.contributor.author | Park, CS | - |
dc.contributor.author | Hong, CS | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-22T10:38:23Z | - |
dc.date.available | 2010-12-22T10:38:23Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0271-9142 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/768 | - |
dc.description.abstract | BACKGROUND: This study was conducted to evaluate whether tissue transglutaminase (tTG) may be involved in airway inflammation of toluene diisocyanate-induced occupational asthma (TDI-OA).
METHODS: We enrolled 93 patients with TDI-OA, 177 asymptomatic exposed subjects, 43 patients with allergic asthma, and 70 unexposed normal controls. The prevalence of serum immunoglobulin G (IgG) to tTG in the TDI-OA group (20.2%) was significantly higher than that in the three other groups (P < 0.001). RESULTS: TDI-OA patients with serum IgG to tTG had significantly lower methacholine PC(20) values (P < 0.02) and significantly higher prevalence of specific immunoglobulin E to vapor type TDI-human serum albumin conjugate (P < 0.01; r(2) = 0.411, P < 0.05). TDI exposure could increase tTG activity via reactive oxygen species (ROS) production, which was found to cross-link with cytokeratin 19 on immunoblot analysis. CONCLUSION: Therefore, TDI exposure may activate tTG via ROS-mediated mechanism in the airway epithelium leading to persistent airway inflammation in TDI-OA patients. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E | - |
dc.subject.MESH | Immunoglobulin G | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Occupational Diseases | - |
dc.subject.MESH | Reactive Oxygen Species | - |
dc.subject.MESH | Respiratory Hypersensitivity | - |
dc.subject.MESH | Toluene 2,4-Diisocyanate | - |
dc.subject.MESH | Transglutaminases | - |
dc.subject.MESH | Young Adult | - |
dc.title | Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma. | - |
dc.type | Article | - |
dc.identifier.pmid | 19562471 | - |
dc.contributor.affiliatedAuthor | 박, 상면 | - |
dc.contributor.affiliatedAuthor | 예, 영민 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s10875-009-9314-8 | - |
dc.citation.title | Journal of clinical immunology | - |
dc.citation.volume | 29 | - |
dc.citation.number | 6 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 786 | - |
dc.citation.endPage | 794 | - |
dc.identifier.bibliographicCitation | Journal of clinical immunology, 29(6). : 786-794, 2009 | - |
dc.identifier.eissn | 1573-2592 | - |
dc.relation.journalid | J002719142 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.