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Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes
DC Field | Value | Language |
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dc.contributor.author | Kim, TN | - |
dc.contributor.author | Park, MS | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Yang, SJ | - |
dc.contributor.author | Lee, KW | - |
dc.contributor.author | Nam, MS | - |
dc.contributor.author | Park, YS | - |
dc.contributor.author | Woo, JT | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Baik, SH | - |
dc.date.accessioned | 2013-04-23 | - |
dc.date.available | 2013-04-23 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/7827 | - |
dc.description.abstract | The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) ≥ 5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG ≥ 7.0 mmol/L or 120-min post-challenge plasma glucose ≥ 11.1 mmol/L or A1C ≥ 6.5 %. For insulin sensitivity and β-cell function classified by the categories of A1C levels, ∆Ins(30-0)/∆Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (≤ 5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and ∆Ins(30-0)/∆Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with ∆Ins(30-0)/∆Glu(30-0), and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes. | - |
dc.language.iso | en | - |
dc.title | Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes | - |
dc.type | Article | - |
dc.identifier.pmid | 22552911 | - |
dc.contributor.affiliatedAuthor | 이, 관우 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s12020-012-9666-3 | - |
dc.citation.title | Endocrine | - |
dc.citation.volume | 42 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2012 | - |
dc.citation.startPage | 584 | - |
dc.citation.endPage | 591 | - |
dc.identifier.bibliographicCitation | Endocrine, 42(3). : 584-591, 2012 | - |
dc.identifier.eissn | 1559-0100 | - |
dc.relation.journalid | J01355008X | - |
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