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Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes

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dc.contributor.authorKim, TN-
dc.contributor.authorPark, MS-
dc.contributor.authorLee, SK-
dc.contributor.authorYang, SJ-
dc.contributor.authorLee, KW-
dc.contributor.authorNam, MS-
dc.contributor.authorPark, YS-
dc.contributor.authorWoo, JT-
dc.contributor.authorKim, YS-
dc.contributor.authorBaik, SH-
dc.date.accessioned2013-04-23-
dc.date.available2013-04-23-
dc.date.issued2012-
dc.identifier.issn1355-008X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7827-
dc.description.abstractThe purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) ≥ 5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG ≥ 7.0 mmol/L or 120-min post-challenge plasma glucose ≥ 11.1 mmol/L or A1C ≥ 6.5 %. For insulin sensitivity and β-cell function classified by the categories of A1C levels, ∆Ins(30-0)/∆Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (≤ 5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and ∆Ins(30-0)/∆Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with ∆Ins(30-0)/∆Glu(30-0), and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes.-
dc.language.isoen-
dc.titleElevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes-
dc.typeArticle-
dc.identifier.pmid22552911-
dc.contributor.affiliatedAuthor이, 관우-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s12020-012-9666-3-
dc.citation.titleEndocrine-
dc.citation.volume42-
dc.citation.number3-
dc.citation.date2012-
dc.citation.startPage584-
dc.citation.endPage591-
dc.identifier.bibliographicCitationEndocrine, 42(3). : 584-591, 2012-
dc.identifier.eissn1559-0100-
dc.relation.journalidJ01355008X-
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Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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