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Neutrophil activation in patients with ASA-induced urticaria.
DC Field | Value | Language |
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dc.contributor.author | Choi, SJ | - |
dc.contributor.author | Ye, YM | - |
dc.contributor.author | Hur, GY | - |
dc.contributor.author | Shin, SY | - |
dc.contributor.author | Han, JH | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-23T04:46:01Z | - |
dc.date.available | 2010-12-23T04:46:01Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0271-9142 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/785 | - |
dc.description.abstract | The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested. | - |
dc.language.iso | en | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Angioedema | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Cytokines | - |
dc.subject.MESH | Drug Hypersensitivity | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypersensitivity, Immediate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neutrophil Activation | - |
dc.subject.MESH | Neutrophils | - |
dc.subject.MESH | Peroxidase | - |
dc.subject.MESH | Urticaria | - |
dc.title | Neutrophil activation in patients with ASA-induced urticaria. | - |
dc.type | Article | - |
dc.identifier.pmid | 18204966 | - |
dc.contributor.affiliatedAuthor | 예, 영민 | - |
dc.contributor.affiliatedAuthor | 한, 재호 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s10875-007-9165-0 | - |
dc.citation.title | Journal of clinical immunology | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 244 | - |
dc.citation.endPage | 249 | - |
dc.identifier.bibliographicCitation | Journal of clinical immunology, 28(3). : 244-249, 2008 | - |
dc.identifier.eissn | 1573-2592 | - |
dc.relation.journalid | J002719142 | - |
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