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Fine-needle aspiration cytology with c-kit immunocytochemical staining in the diagnosis of Warthin's tumor

DC Field Value Language
dc.contributor.authorKim, JY-
dc.contributor.authorYoo, YS-
dc.contributor.authorKwon, JE-
dc.contributor.authorKim, HJ-
dc.contributor.authorPark, K-
dc.date.accessioned2013-04-23T04:51:04Z-
dc.date.available2013-04-23T04:51:04Z-
dc.date.issued2012-
dc.identifier.issn0001-5547-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7864-
dc.description.abstractOBJECTIVE: Although Warthin's tumor (WT) is one of a few salivary gland tumors that have distinct cytologic findings, it can be confused with malignant tumors at times. We assessed the overall accuracy, unusual features, and diagnostic points of fine-needle aspiration (FNA) of WT.



STUDY DESIGN: We retrospectively collected histologically confirmed WT from 21 patients and reviewed preoperative FNA slides. Smears were subject to immunocytochemical staining for carcinoembryonic antigen (CEA) and c-kit and compared to metastatic squamous cell carcinoma.



RESULTS: All of the cases were in the parotid gland; the mean size was 3.6 ± 1.2 cm. Of 21 patients, 19 were male (age 59.7 ± 9.4 years) and had a history of smoking. The initial FNA diagnoses were WT (11 patients, 52.4%), benign lesion (7 patients, 33.3%), and malignant neoplasm (3 patients, 14.3%). Only 6 patients (28.6%) showed typical FNA features of WT. The dominant cell types in the smears were macrophages (76.2%), squamous-like cells (66.7%), oncocytes (61.9%), and lymphoid cells (57.1%). Some showed atypical degenerated features, a necrotic background, and inflammatory cells, leading to misdiagnosis. CEA positivity and c-kit positivity in WT were noted in 0 and 75.0% of cases, respectively, whereas metastatic squamous cell carcinoma showed positive rates of 16.7 and 0%, respectively.



CONCLUSION: Awareness of potential sources of misdiagnosis together with combination of c-kit/CEA immunostaining may result in an increased diagnostic rate of WT in FNA.
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dc.language.isoen-
dc.subject.MESHAdenolymphoma-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHCarcinoembryonic Antigen-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHParotid Gland-
dc.subject.MESHProto-Oncogene Proteins c-kit-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHStaining and Labeling-
dc.titleFine-needle aspiration cytology with c-kit immunocytochemical staining in the diagnosis of Warthin's tumor-
dc.typeArticle-
dc.identifier.pmid23075886-
dc.identifier.urlhttp://www.karger.com/?DOI=000339195&typ=pdf-
dc.contributor.affiliatedAuthor권, 지은-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000339195-
dc.citation.titleActa cytologica-
dc.citation.volume56-
dc.citation.number5-
dc.citation.date2012-
dc.citation.startPage474-
dc.citation.endPage480-
dc.identifier.bibliographicCitationActa cytologica, 56(5). : 474-480, 2012-
dc.identifier.eissn1938-2650-
dc.relation.journalidJ000015547-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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