Cited 0 times in Scipus Cited Count

A MAP kinase pathway is implicated in the pseudohyphal induction by hydrogen peroxide in Candica albicans.

DC Field Value Language
dc.contributor.authorSrinivasa, K-
dc.contributor.authorKim, J-
dc.contributor.authorYee, S-
dc.contributor.authorKim, W-
dc.contributor.authorChoi, W-
dc.date.accessioned2013-04-24T05:33:19Z-
dc.date.available2013-04-24T05:33:19Z-
dc.date.issued2012-
dc.identifier.issn1016-8478-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7929-
dc.description.abstractHydrogen peroxide (H(2)O(2)) functions as a ubiquitous intracellular messenger besides as an oxidative stress molecule. This dual role is based on the distinct cellular responses against different concentrations of H(2)O(2). Previously, we demonstrated that both low (> 1 mM) and high (4-10 mM) doses of exogenous H(2)O(2) induce filamentous growth with distinct cell morphology and growth rate in Candida albicans, suggesting the different transcription response. In this study, we revealed that the sub-toxic and toxic levels of H(2)O(2) indeed induced pseudohyphae, but not true hyphae. Supporting this, several hyphae-specific genes that are expressed in true hyphae induced by serum were not detected in either sub-toxic or toxic H(2)O(2) condition. A DNA microarray analysis was conducted to reveal the transcription profiles in cells treated with sub-toxic and toxic conditions of H(2)O(2). Under the sub-toxic condition, a small number of genes involved in cell proliferation and metabolism were up-regulated, whereas a large number of genes were up-regulated in the toxic condition where the genes required for growth and proliferation were selectively restricted. For pseudohyphal induction by sub-toxic H(2)O(2), Cek1 MAPK activating the transcription factor Cph1 was shown to be important. The absence of expression of several hyphae-specific genes known to be downstream targets of Cph1-signaling pathway for true hyphae formation suggests that the Cek1-mediated signaling pathway is not solely responsible for pseudohyphal formation by subtoxic H(2)O(2) and, but instead, complex networking pathway may exists by the activation of different regulators.-
dc.language.isoen-
dc.subject.MESHCandida albicans-
dc.subject.MESHCell Proliferation-
dc.subject.MESHFungal Proteins-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHydrogen Peroxide-
dc.subject.MESHHyphae-
dc.subject.MESHMAP Kinase Signaling System-
dc.subject.MESHMitogen-Activated Protein Kinase 3-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHOxidative Stress-
dc.subject.MESHTranscription Factors-
dc.titleA MAP kinase pathway is implicated in the pseudohyphal induction by hydrogen peroxide in Candica albicans.-
dc.typeArticle-
dc.identifier.pmid22358510-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887715/-
dc.contributor.affiliatedAuthor김, 완기-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s10059-012-2244-y-
dc.citation.titleMolecules and cells-
dc.citation.volume33-
dc.citation.number2-
dc.citation.date2012-
dc.citation.startPage183-
dc.citation.endPage193-
dc.identifier.bibliographicCitationMolecules and cells, 33(2). : 183-193, 2012-
dc.identifier.eissn0219-1032-
dc.relation.journalidJ010168478-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse