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Therapeutic responses and prognosis in adult-onset Still's disease

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dc.contributor.authorKim, HA-
dc.contributor.authorSung, JM-
dc.contributor.authorSuh, CH-
dc.date.accessioned2013-04-24T06:27:20Z-
dc.date.available2013-04-24T06:27:20Z-
dc.date.issued2012-
dc.identifier.issn0172-8172-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7942-
dc.description.abstractTo date, the treatment of adult-onset Still's disease (AOSD) has been largely empirical; therefore, this study was conducted to investigate the response to therapy and prognostic factors of AOSD. Fifty-four Korean patients with AOSD were enrolled based on Yamaguchi's criteria. We retrospectively analyzed the treatments and prognosis. Thirty-nine patients (72.2%) were female, and the average age at disease onset was 37.3 years. Twenty-nine patients had a monocyclic disease (53.7%), five had a polycyclic (9.3%) and fifteen had a chronic articular disease (27.7%) and five died (9.3%). The elevated ESR and corticosteroids refractoriness were associated with poor prognosis (P = 0.023 and P = 0.009, respectively). The patients that died were older than those survived (49.2 ± 11.8 vs. 42.2 ± 14 year old, P = 0.024). Forty-two patients were treated with non-steroidal anti-inflammatory drugs; however, they also needed corticosteroids and intravenous immunoglobulin (IVIG). Among 50 patients treated with high-dose corticosteroids, 21 patients (42%) were resistant to corticosteroids and treated with IVIG or anti-tumor necrosis factor (TNF) agents. Of the 23 patients medicated with IVIG, the prognosis was better in IVIG-responsive patients, indicating a therapeutic effect. Methotrexate was the most commonly used disease modifying anti-rheumatic drugs (27 patients, 50%), and the corticosteroid requirements were lower in the methotrexate-responsive patients. Approximately half of AOSD patients had a poor prognosis and were corticosteroids resistance. An elevated ESR and non-response to corticosteroids were associated with poor prognosis. Patients who died were older than those survived.-
dc.language.isoen-
dc.subject.MESHAdrenal Cortex Hormones-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.MESHBlood Sedimentation-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHDrug Resistance-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulins, Intravenous-
dc.subject.MESHImmunosuppressive Agents-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHStill's Disease, Adult-Onset-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleTherapeutic responses and prognosis in adult-onset Still's disease-
dc.typeArticle-
dc.identifier.pmid21274538-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor서, 창희-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00296-011-1801-6-
dc.citation.titleRheumatology international-
dc.citation.volume32-
dc.citation.number5-
dc.citation.date2012-
dc.citation.startPage1291-
dc.citation.endPage1298-
dc.identifier.bibliographicCitationRheumatology international, 32(5). : 1291-1298, 2012-
dc.identifier.eissn1437-160X-
dc.relation.journalidJ001728172-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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