Cited 0 times in Scipus Cited Count

Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

DC Field Value Language
dc.contributor.authorYoon, MJ-
dc.contributor.authorKim, EH-
dc.contributor.authorKwon, TK-
dc.contributor.authorPark, SA-
dc.contributor.authorChoi, KS-
dc.date.accessioned2013-04-25T01:26:02Z-
dc.date.available2013-04-25T01:26:02Z-
dc.date.issued2012-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7957-
dc.description.abstractIn this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na(+)/Ca(2+) exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca(2+) overload and effectively induce paraptosis in malignant breast cancer cells.-
dc.language.isoen-
dc.subject.MESHAntineoplastic Agents, Phytogenic-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHBoronic Acids-
dc.subject.MESHBreast Neoplasms-
dc.subject.MESHCalcium-
dc.subject.MESHCell Death-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHClonazepam-
dc.subject.MESHCurcumin-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEndoplasmic Reticulum-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMitochondria-
dc.subject.MESHProtease Inhibitors-
dc.subject.MESHProteasome Endopeptidase Complex-
dc.subject.MESHProteasome Inhibitors-
dc.subject.MESHPyrazines-
dc.subject.MESHSodium-Calcium Exchanger-
dc.subject.MESHThiazepines-
dc.subject.MESHTime Factors-
dc.titleSimultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells-
dc.typeArticle-
dc.identifier.pmid22634500-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0304-3835(12)00312-6-
dc.contributor.affiliatedAuthor최, 경숙-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.canlet.2012.05.018-
dc.citation.titleCancer letters-
dc.citation.volume324-
dc.citation.number2-
dc.citation.date2012-
dc.citation.startPage197-
dc.citation.endPage209-
dc.identifier.bibliographicCitationCancer letters, 324(2). : 197-209, 2012-
dc.identifier.eissn1872-7980-
dc.relation.journalidJ003043835-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse