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Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Yoon, MJ | - |
dc.contributor.author | Kim, EH | - |
dc.contributor.author | Kwon, TK | - |
dc.contributor.author | Park, SA | - |
dc.contributor.author | Choi, KS | - |
dc.date.accessioned | 2013-04-25T01:26:02Z | - |
dc.date.available | 2013-04-25T01:26:02Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/7957 | - |
dc.description.abstract | In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na(+)/Ca(2+) exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca(2+) overload and effectively induce paraptosis in malignant breast cancer cells. | - |
dc.language.iso | en | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols | - |
dc.subject.MESH | Boronic Acids | - |
dc.subject.MESH | Breast Neoplasms | - |
dc.subject.MESH | Calcium | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Clonazepam | - |
dc.subject.MESH | Curcumin | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Endoplasmic Reticulum | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mitochondria | - |
dc.subject.MESH | Protease Inhibitors | - |
dc.subject.MESH | Proteasome Endopeptidase Complex | - |
dc.subject.MESH | Proteasome Inhibitors | - |
dc.subject.MESH | Pyrazines | - |
dc.subject.MESH | Sodium-Calcium Exchanger | - |
dc.subject.MESH | Thiazepines | - |
dc.subject.MESH | Time Factors | - |
dc.title | Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells | - |
dc.type | Article | - |
dc.identifier.pmid | 22634500 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0304-3835(12)00312-6 | - |
dc.contributor.affiliatedAuthor | 최, 경숙 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.canlet.2012.05.018 | - |
dc.citation.title | Cancer letters | - |
dc.citation.volume | 324 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2012 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | Cancer letters, 324(2). : 197-209, 2012 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.relation.journalid | J003043835 | - |
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