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Isotype and IgG subclass distribution of autoantibody response to alpha-enolase protein in adult patients with severe asthma.
DC Field | Value | Language |
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dc.contributor.author | Lee, HA | - |
dc.contributor.author | Kwon, B | - |
dc.contributor.author | Hur, GY | - |
dc.contributor.author | Choi, SJ | - |
dc.contributor.author | Nahm, DH | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-24T02:31:07Z | - |
dc.date.available | 2010-12-24T02:31:07Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/800 | - |
dc.description.abstract | PURPOSE: A possible involvement of autoimmune mechanism in the pathogenesis of bronchial asthma has been proposed. Recently, alpha-enolase protein was identified as a major autoantigen recognized by circulating IgG autoantibodies in patients with severe asthma. To evaluate a possible pathogenetic significance of these autoantibodies in severe asthma, isotype (IgG, IgA, IgM, and IgE) and IgG subclass (IgG1, IgG2, IgG3, and IgG4) distributions of autoantibodies to recombinant human alpha-enolase protein were analyzed.
PATIENTS AND METHODS: We examined serum samples from 10 patients with severe asthma and 7 patients with mild-to-moderate asthma, and 5 healthy controls by immunoblot analysis. Severe asthma was defined as patients having at least 1 severe asthmatic exacerbation requiring an emergency department visit or admission in the last year despite continuous typical therapies. RESULTS: IgG1 was the predominant IgG subclass antibody response to alpha-enolase protein in patients with severe asthma. IgG1 autoantibody to alpha-enolase protein was detected in 7 of 10 patients with severe asthma (70%), 1 of 7 patients with mild-to-moderate asthma (14.3%), and none of 5 healthy controls (0%) (chi-square test; p < 0.05). IgA, IgM, and IgE autoantibodies to alpha-enolase protein could not be detected in patients with severe asthma. CONCLUSION: IgG1 subclass was the predominant type of autoantibody response to alpha-enolase protein in patients with severe asthma, suggests a possibility of IgG1 autoantibody-mediated complement activation in the pathogenesis of severe asthma. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Autoantibodies | - |
dc.subject.MESH | Autoantigens | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Complement Activation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin G | - |
dc.subject.MESH | Immunoglobulin Isotypes | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphopyruvate Hydratase | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.subject.MESH | Young Adult | - |
dc.title | Isotype and IgG subclass distribution of autoantibody response to alpha-enolase protein in adult patients with severe asthma. | - |
dc.type | Article | - |
dc.identifier.pmid | 19108015 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628024/ | - |
dc.contributor.affiliatedAuthor | 남, 동호 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.3349/ymj.2008.49.6.923 | - |
dc.citation.title | Yonsei medical journal | - |
dc.citation.volume | 49 | - |
dc.citation.number | 6 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 923 | - |
dc.citation.endPage | 930 | - |
dc.identifier.bibliographicCitation | Yonsei medical journal, 49(6). : 923-930, 2008 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.relation.journalid | J005135796 | - |
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