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Matrix metalloproteinase-2, -9, -12, and tissue inhibitor of metalloproteinase 2 gene polymorphisms and cutaneous expressions in patients with Behçet's disease

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dc.contributor.authorPark, KS-
dc.contributor.authorMin, Y-
dc.contributor.authorPark, SR-
dc.contributor.authorKim, EH-
dc.contributor.authorLee, DJ-
dc.contributor.authorBang, D-
dc.contributor.authorLee, ES-
dc.date.accessioned2013-04-29T04:22:07Z-
dc.date.available2013-04-29T04:22:07Z-
dc.date.issued2012-
dc.identifier.issn0001-2815-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8073-
dc.description.abstractMatrix metalloproteinases (MMPs) induce leukocyte migration into inflammation sites that lead to either promotion or repression of inflammation by activating or inactivating cytokines. An increased level of MMP-9 and a decreased level of MMP-2 have been observed in Behçet's disease (BD). This study was performed to analyze the relationship between MMP-2, -9, -12 and the tissue inhibitor of metalloproteinase-2 (TIMP-2) promoter polymorphisms in developing BD. The expression of MMP-2 and -9 was also evaluated in the skin of BD. The MMPs and TIMP-2 polymorphisms were confirmed by using polymerase chain reaction-restriction fragment length polymorphism in 251 BD and 312 controls. Cutaneous expression of MMP-2 and -9 in 17 BD patients with erythema nodosum (EN) or EN-like lesion was compared with 14 patients with idiopathic EN by immunohistochemical stains. The frequency of MMP-2-1575*G/*G and MMP-2-735*C/*C genotypes was shown to be lower in BD, whereas MMP-9-1562*C/*C was significantly higher in BD compared with the controls. The frequency of common haplotype MMP-2-1575*G -735*C was significantly lower in BD patients than in controls (P = 0.0046, permutation P = 0.009). No significant differences were observed between BD and controls in the allele and genotype frequencies of MMP-12-82A>G or TIMP-2-418G>C polymorphisms. The tissue expression of MMP-2, shown by immunohistochemistry, was significantly lower in BD compared with the controls. However, the expression of MMP-9 was significantly higher in BD. These results suggest that MMP-2 and -9 could each modulate the development of BD in opposite directions. Major genotypes of the MMP-2-1575*G/*G and MMP-2-735*C/*C and the common MMP-2-1575*G -735*C haplotype may provide some protection against development of BD, while MMP-9-1562*C/*C may promote the disease. The reciprocal expression of MMP-2 and -9 in the skin tissue of BD was also confirmed.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAlleles-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHBehcet Syndrome-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHErythema Nodosum-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHaplotypes-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 12-
dc.subject.MESHMatrix Metalloproteinase 2-
dc.subject.MESHMatrix Metalloproteinase 9-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHPolymorphism, Restriction Fragment Length-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSkin-
dc.subject.MESHTissue Inhibitor of Metalloproteinase-2-
dc.titleMatrix metalloproteinase-2, -9, -12, and tissue inhibitor of metalloproteinase 2 gene polymorphisms and cutaneous expressions in patients with Behçet's disease-
dc.typeArticle-
dc.identifier.pmid22428754-
dc.contributor.affiliatedAuthor이, 은소-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1399-0039.2012.01863.x-
dc.citation.titleTissue antigens-
dc.citation.volume79-
dc.citation.number5-
dc.citation.date2012-
dc.citation.startPage333-
dc.citation.endPage339-
dc.identifier.bibliographicCitationTissue antigens, 79(5). : 333-339, 2012-
dc.identifier.eissn1399-0039-
dc.relation.journalidJ000012815-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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