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Matrix metalloproteinase-2, -9, -12, and tissue inhibitor of metalloproteinase 2 gene polymorphisms and cutaneous expressions in patients with Behçet's disease
DC Field | Value | Language |
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dc.contributor.author | Park, KS | - |
dc.contributor.author | Min, Y | - |
dc.contributor.author | Park, SR | - |
dc.contributor.author | Kim, EH | - |
dc.contributor.author | Lee, DJ | - |
dc.contributor.author | Bang, D | - |
dc.contributor.author | Lee, ES | - |
dc.date.accessioned | 2013-04-29T04:22:07Z | - |
dc.date.available | 2013-04-29T04:22:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0001-2815 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/8073 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) induce leukocyte migration into inflammation sites that lead to either promotion or repression of inflammation by activating or inactivating cytokines. An increased level of MMP-9 and a decreased level of MMP-2 have been observed in Behçet's disease (BD). This study was performed to analyze the relationship between MMP-2, -9, -12 and the tissue inhibitor of metalloproteinase-2 (TIMP-2) promoter polymorphisms in developing BD. The expression of MMP-2 and -9 was also evaluated in the skin of BD. The MMPs and TIMP-2 polymorphisms were confirmed by using polymerase chain reaction-restriction fragment length polymorphism in 251 BD and 312 controls. Cutaneous expression of MMP-2 and -9 in 17 BD patients with erythema nodosum (EN) or EN-like lesion was compared with 14 patients with idiopathic EN by immunohistochemical stains. The frequency of MMP-2-1575*G/*G and MMP-2-735*C/*C genotypes was shown to be lower in BD, whereas MMP-9-1562*C/*C was significantly higher in BD compared with the controls. The frequency of common haplotype MMP-2-1575*G -735*C was significantly lower in BD patients than in controls (P = 0.0046, permutation P = 0.009). No significant differences were observed between BD and controls in the allele and genotype frequencies of MMP-12-82A>G or TIMP-2-418G>C polymorphisms. The tissue expression of MMP-2, shown by immunohistochemistry, was significantly lower in BD compared with the controls. However, the expression of MMP-9 was significantly higher in BD. These results suggest that MMP-2 and -9 could each modulate the development of BD in opposite directions. Major genotypes of the MMP-2-1575*G/*G and MMP-2-735*C/*C and the common MMP-2-1575*G -735*C haplotype may provide some protection against development of BD, while MMP-9-1562*C/*C may promote the disease. The reciprocal expression of MMP-2 and -9 in the skin tissue of BD was also confirmed. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Behcet Syndrome | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Erythema Nodosum | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 12 | - |
dc.subject.MESH | Matrix Metalloproteinase 2 | - |
dc.subject.MESH | Matrix Metalloproteinase 9 | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Polymorphism, Genetic | - |
dc.subject.MESH | Polymorphism, Restriction Fragment Length | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Skin | - |
dc.subject.MESH | Tissue Inhibitor of Metalloproteinase-2 | - |
dc.title | Matrix metalloproteinase-2, -9, -12, and tissue inhibitor of metalloproteinase 2 gene polymorphisms and cutaneous expressions in patients with Behçet's disease | - |
dc.type | Article | - |
dc.identifier.pmid | 22428754 | - |
dc.contributor.affiliatedAuthor | 이, 은소 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/j.1399-0039.2012.01863.x | - |
dc.citation.title | Tissue antigens | - |
dc.citation.volume | 79 | - |
dc.citation.number | 5 | - |
dc.citation.date | 2012 | - |
dc.citation.startPage | 333 | - |
dc.citation.endPage | 339 | - |
dc.identifier.bibliographicCitation | Tissue antigens, 79(5). : 333-339, 2012 | - |
dc.identifier.eissn | 1399-0039 | - |
dc.relation.journalid | J000012815 | - |
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