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LPS induces melanogenesis through p38 MAPK activation in human melanocytes.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, JH | - |
dc.contributor.author | Jin, SH | - |
dc.contributor.author | Kang, HY | - |
dc.date.accessioned | 2010-12-27T04:44:28Z | - |
dc.date.available | 2010-12-27T04:44:28Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0340-3696 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/832 | - |
dc.description.abstract | We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to induce the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase protein in cells. Stimulation of melanocytes with LPS led to time dependent phosphorylation of p38 MAPK. Furthermore, p38 MAPK functionally regulated the LPS-induced melanin formation in melanocytes; a p38 MAPK inhibitor, SB203580, almost completely attenuated the LPS-mediated up-regulation of melanin synthesis and induction of MITF and tyrosinase expression. These findings indicate that activation of p38 MAPK plays an important role in LPS-induced melanogenesis by up-regulating MITF and tyrosinase expression. | - |
dc.language.iso | en | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Lineage | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imidazoles | - |
dc.subject.MESH | Lipopolysaccharides | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Melanins | - |
dc.subject.MESH | Melanocytes | - |
dc.subject.MESH | Microphthalmia-Associated Transcription Factor | - |
dc.subject.MESH | Monophenol Monooxygenase | - |
dc.subject.MESH | Pyridines | - |
dc.subject.MESH | Skin Pigmentation | - |
dc.subject.MESH | Transcriptional Activation | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases | - |
dc.title | LPS induces melanogenesis through p38 MAPK activation in human melanocytes. | - |
dc.type | Article | - |
dc.identifier.pmid | 18478240 | - |
dc.contributor.affiliatedAuthor | 강, 희영 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s00403-008-0863-0 | - |
dc.citation.title | Archives of dermatological research | - |
dc.citation.volume | 300 | - |
dc.citation.number | 6 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 329 | - |
dc.identifier.bibliographicCitation | Archives of dermatological research, 300(6). : 325-329, 2008 | - |
dc.identifier.eissn | 1432-069X | - |
dc.relation.journalid | J003403696 | - |
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