Fabrication of scaffold-free engineered cartilage using passaged chondrocytes in the presence of insuline like growth factor 1 (IGF-1)

Abstract

Two passaged (P2) immature porcine articular chondrocytes were used to fabricate an engineered cartilage tissue in an in vitro scaffold-free system with or without insulin like growth factor 1 (IGF-1). This study shows the possibility of the fabrication of structurally regular neocartilage tissue using passaged chondrocytes in the scaffold-free system with insulin like growth factor-1 (IGF-1).