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Correlation of Cyclooxygenase-2 Expression and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract

Other Title
상부요로 이행세포암에서 Cyclooxygenase-2 발현 및 미세혈관 밀도와 예후와의 연관성
Authors
차, 민호 | 조, 대성 | 임, 현이  | 조, 강수 | 홍, 성준 | 조, 남훈 | 김, 선일  | 안, 현수  | 김, 세중
Citation
Korean journal of urology, 48(4). : 376-382, 2007
Journal Title
Korean journal of urology
ISSN
0494-4747
Abstract
Purpose: The aim of this study was to investigate the relationship of cyclooxygenase(COX)-2 expression and microvessel density(MVD), a reflection of angiogenesis, with prognosis in patients with transitional cell carcinoma of the upper urinary tract(TCC-UUT).
Materials & Methods: Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 91 patients, who had undergone radical nephroureterectomy, were examined immunohistochemically using antibodies against COX-2 and CD34. MVD was determined with CD34-stained slides. The expression patterns of COX-2 and MVD were compared with the clinicopathological variables.
Results: The COX-2 expression was significantly correlated with T stage (p=0.002), N stage(p=0.010), and grade(p=0.027). MVD was also significantly correlated with T stage(p<0.001), N stage(p=0.002), and grade (p=0.001). The COX-2 expression was significantly correlated with MVD (p=0.001). The survival rate of patients with COX-2 positive tumors or high MVD was significantly lower than that of patients with COX-2 negative tumors or low MVD, respectively(p=0.0013, p=0.0312). Univariate analyses identified T stage, N stage, grade, COX-2 expression, and MVD as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that T stage was the only independent prognostic factor.
Conclusion: The increased expression of COX-2 and MVD is associated with a worse prognosis in TCC-UUT. The COX-2 expression is correlated with MVD. These results suggest that COX-2 may play an important role in the progression of TCC-UUT and angiogenesis may be affected by COX-2 during the progression of TCC-UUT.
Keywords

DOI
10.4111/kju.2007.48.4.376
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Ajou Authors
김, 선일  |  김, 세중  |  안, 현수  |  임, 현이
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