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Cyclooxygenase-2 expression in human thyroid disease.
DC Field | Value | Language |
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dc.contributor.author | Lee, KJ | - |
dc.contributor.author | Jung, YS | - |
dc.contributor.author | Kim, WH | - |
dc.contributor.author | Yoon, TI | - |
dc.contributor.author | Joo, HJ | - |
dc.contributor.author | Soh, EY | - |
dc.date.accessioned | 2010-12-27T06:58:29Z | - |
dc.date.available | 2010-12-27T06:58:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0391-4097 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/844 | - |
dc.description.abstract | OBJECTIVES: Cyclooxygenase (COX)-2, which is the inducible form of the COX enzyme for prostaglandin synthesis and a key mediator of epithelial cell growth, has been shown to be up-regulated in gastrointestinal cancers. Additionally, regular intake of other non-steroidal anti-inflammatory drugs (NSAID) is known to decrease the incidence of these cancers. Therefore, the goals of the present study were to determine the possible involvement of COX-2 in human thyroid diseases.
METHODS: We used immunohistochemical staining and Western blot analysis to characterize the expression of COX-2 proteins in thyroid tissues from 64 patients with thyroiditis, benign tumors, and malignant tumors with or without metastasis. Immunoreactivity scores were calculated by multiplication of the determined grades. RESULTS: COX-2 proteins were not expressed in normal thyroid tissues. However, each type of tumor tissue showed intense bands of COX-2 protein expression in Western blot analyses, and the immunoreactivity scores were 7.67+/-1.17 (SD) for thyroiditis, 7.87+/-0.9 for benign tumors, 7.53+/-1.53 for follicular cancer, 7.63+/-1.11 for papillary cancer without metastasis, and 7.17+/-1.55 for papillary cancer with metastasis. No significant differences were found in the levels of COX-2 expression between different tumor tissue types. CONCLUSION: No significant correlations were observed between clinical and/or pathological characteristics of thyroid tumors and the intensity of COX-2 protein expression. In addition, we found no difference in COX-2 protein expression between thyroiditis and thyroid tumors. Thus, up-regulation of COX-2 protein synthesis in human thyroid diseases does not appear to be of clinical significance. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adenoma | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Carcinoma | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Thyroid Neoplasms | - |
dc.subject.MESH | Thyroiditis, Autoimmune | - |
dc.subject.MESH | Up-Regulation | - |
dc.title | Cyclooxygenase-2 expression in human thyroid disease. | - |
dc.type | Article | - |
dc.identifier.pmid | 18362501 | - |
dc.identifier.url | http://www.kurtis.it/abs/index.cfm?id_articolo_numero=4455 | - |
dc.contributor.affiliatedAuthor | 정, 용식 | - |
dc.contributor.affiliatedAuthor | 김, 욱환 | - |
dc.contributor.affiliatedAuthor | 주, 희재 | - |
dc.contributor.affiliatedAuthor | 소, 의영 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/BF03345576 | - |
dc.citation.title | Journal of endocrinological investigation | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 118 | - |
dc.identifier.bibliographicCitation | Journal of endocrinological investigation, 31(2). : 111-118, 2008 | - |
dc.identifier.eissn | 1720-8386 | - |
dc.relation.journalid | J003914097 | - |
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