Ebastine (ebastelⓡ) is one of the most frequently used antihistamines for allergic diseases. It is a long-acting H1 receptor antagonist belonging to the family of piperidines. Recently, we experienced 2 cases of patients who developed urticaria after taking ebastine. There have been a few reported cases of urticaria induced by antihistamines, such as cetirizine, levocetirizine, fexofenadine, clorpheniramine and hydroxyzine. To our best knowledge, this is the first case of urticaria caused by ebastine.