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Deep brain stimulation in Parkinson disease with valosin-containing protein gene mutation

Authors
Kim, YS | Park, DG  | Kim, MS | Yoon, JH
Citation
European journal of neurology, 30(8). : 2583-2586, 2023
Journal Title
European journal of neurology
ISSN
1351-51011468-1331
Abstract
Background and purpose: Mutations in the gene encoding valosin-containing protein (VCP) are related to myriad medical conditions, including familial amyotrophic lateral sclerosis, inclusion body myopathy, and frontotemporal dementia. There are several reports of a link between these mutations and early onset Parkinson disease (PD). Case description: We report a 53-year-old PD patient with VCP mutation who later developed motor complications, thus receiving subthalamic nucleus deep brain stimulation (DBS) at the age of 56 years. However, myopathy emerged 1.5 years after surgery. Conclusions: With the phenotype variability of VCP, DBS should be carefully evaluated, considering the possible unfavorable long-term outcomes due to other symptoms of this mutation.
Keywords

MeSH

DOI
10.1111/ene.15824
PMID
37170789
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Ajou Authors
박, 동규  |  윤, 정한
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